Which statement about salicylate analgesics is NOT true?

Salicylate analgesics, which include compounds like aspirin, are indeed among the oldest nonopioid analgesics used for pain relief and anti-inflammatory purposes. Also, these analgesics can be combined with caffeine to enhance their analgesic effects, which is commonly seen in some over-the-counter pain relievers.

However, it is not accurate to state that salicylate analgesics do not cause gastric discomfort. In fact, one of the notable side effects of salicylates, particularly aspirin, is the potential for gastric irritation. They can lead to gastrointestinal issues such as dyspepsia, ulcers, and bleeding because these compounds can irritate the stomach lining and interfere with the production of protective gastric mucus.

Thus, the statement that salicylate analgesics do not cause gastric discomfort is incorrect, making it the right choice for the question asked.