Which of the following can be a limiting factor of nicotinic acid use?

Nicotinic acid, commonly known as niacin, is utilized primarily for its lipid-modifying effects, particularly in managing cholesterol levels. While cost, availability, and dosage limitations may seem relevant considerations, side effects are a major factor that can significantly limit its use in clinical practice.

Individuals using nicotinic acid may experience a range of side effects, with one of the most notable being flushing, which is caused by prostaglandin release and can be uncomfortable for patients. Other potential side effects include gastrointestinal issues such as nausea, vomiting, and diarrhea, as well as more serious effects like liver toxicity when used in high doses. These adverse reactions can discourage patients from adhering to treatment regimens, leading healthcare providers to reconsider the appropriateness of prescribing nicotinic acid. Therefore, due to the potential for side effects to impact patient compliance and overall quality of life, they serve as a prominent limiting factor in the use of nicotinic acid.