Which medication is known to NOT cause ototoxicity?

Methotrexate is known to not cause ototoxicity. Ototoxicity refers to damage to the ear—particularly the inner ear or auditory nerve—due to certain medications, resulting in hearing loss or balance issues. While Gentamicin is an antibiotic that can cause ototoxicity, particularly in high doses or prolonged use, and Furosemide, a loop diuretic, is also associated with ototoxic effects especially at high doses, aspirin can lead to reversible hearing changes and tinnitus at high doses, but it is less commonly recognized as producing significant ototoxicity compared to the above.

Methotrexate primarily acts as an anti-metabolite and is used in cancer therapy and autoimmune diseases. Its side effects are generally not related to auditory function, which solidifies its distinction from the other medications listed. Understanding the specific side effects of these drugs helps to manage patient care effectively, especially in populations at risk for hearing loss.