What is the main function of TNF inhibitors in arthritis therapy?

The main function of TNF inhibitors in arthritis therapy is to prevent inflammation of the joints. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays a crucial role in the inflammatory processes associated with arthritis, particularly in autoimmune disorders like rheumatoid arthritis. By inhibiting TNF, these drugs effectively reduce inflammation, leading to decreased pain and improved functional outcomes in patients.

This action helps to alleviate symptoms such as swelling and stiffness in the joints, ultimately improving the quality of life for those affected by arthritis. TNF inhibitors do not cure the disease, nor do they promote joint swelling or enhance the immune response; rather, their primary role is to manage the inflammatory reaction that contributes to joint damage and discomfort in these conditions.