What is a true statement regarding suppositories?

Suppositories are medications designed to be inserted into the rectum, where they dissolve and are absorbed into the bloodstream. One common side effect associated with their use is rectal irritation, which may occur due to the physical insertion of the suppository or the ingredients within it. This irritation can manifest as discomfort, burning, or a sensation of fullness in the rectal area.

While suppositories are indeed used for various purposes, including relieving constipation, that does not mean they are exclusively intended for this condition, which is why the first statement is too narrow. The possibility of rectal irritation is an important consideration for anyone using suppositories, making the statement about their potential to cause irritation accurate. Furthermore, while suppositories can be safer than certain oral medications in specific contexts—for example, in patients who have difficulty swallowing or those who experience nausea—this safety factor is not universally applicable and depends on the specific medication and individual circumstances.

Lastly, it's misleading to assert that suppositories have no side effects, as all medications have the potential for side effects, including suppositories. Therefore, the statement regarding the potential for rectal irritation stands out as a true and relevant point regarding the use of suppositories.