What effect does nicotinic acid have on lipid levels?

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Prepare for the UCF HSC3147 Introduction to Pharmacology Test. Access flashcards and multiple choice questions with hints and explanations. Enhance your exam readiness!

Nicotinic acid, also known as niacin, has a well-documented effect on lipid levels in the body. It is primarily used in the management of dyslipidemia, particularly to improve lipid profiles.

The correct answer highlights that nicotinic acid reduces levels of low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL) while simultaneously raising high-density lipoprotein (HDL). This action is particularly significant because:

  1. Reduction of LDL and VLDL: Nicotinic acid decreases the production of these lipoproteins in the liver. By lowering LDL and VLDL levels, it helps to reduce the risk of atherosclerosis and associated cardiovascular diseases.

  2. Increase of HDL: One of the most beneficial effects of nicotinic acid is its ability to raise HDL levels, which is often referred to as "good cholesterol." Higher HDL levels are associated with a lower risk of heart disease, as HDL helps transport cholesterol away from the arteries and back to the liver.

Overall, nicotinic acid plays a crucial role in balancing lipid levels, promoting cardiovascular health by reducing atherogenic lipoproteins and enhancing protective lipoproteins. This comprehensive lipid-modifying