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Antipsychotics are also commonly referred to as major tranquilizers and neuroleptics. This designation stems from their historical use in treating more severe mental health conditions, particularly psychotic disorders such as schizophrenia. The term "major tranquilizers" emphasizes their efficacy in managing significant agitation and psychotic symptoms, whereas "neuroleptics" refers to their action of altering neurological functioning, particularly by influencing neurotransmitter systems like dopamine.

While the other terms listed relate to different classes of medications, they do not accurately describe antipsychotics. For instance, minor tranquilizers are typically associated with medications that help relieve anxiety. Psychomimetics refer to substances that mimic psychosis or alter mood and perception, and antidepressants are medicines used primarily to treat depression. Therefore, "major tranquilizers and neuroleptics" best encapsulates the function and classification of antipsychotic medications.