Toxic effects of chemotherapeutic agents may include which of the following?

Chemotherapeutic agents can indeed lead to a variety of toxic effects on different organ systems, and cardiotoxicity is one of the well-documented consequences associated with certain classes of chemotherapy. Specific drugs, especially those used in the treatment of cancers, may cause damage to heart tissues, leading to conditions such as cardiomyopathy and heart failure. This toxicity can arise from the direct effects of the drugs on cardiac cells or as a result of cumulative doses over time.

Many chemotherapeutic drugs, such as doxorubicin, are particularly known for their potential to induce cardiotoxicity. The mechanisms may involve oxidative stress and the disruption of cellular signaling pathways critical for heart function.

While other toxicities, such as pulmonary toxicity, dermatotoxicity, and gastrotoxicity, can also occur with certain chemotherapeutic agents, cardiotoxicity is highlighted due to its significant impact on patient outcomes and the need for monitoring during treatment. This focus is critical as it informs treatment planning, the need for cardioprotective strategies, and the monitoring of patients who are receiving these therapies.