Topical anti-infectives are indicated for superficial wounds but not for deep penetrating wounds.

Topical anti-infectives are specifically designed to be applied to the skin and are effective in treating localized infections that occur in superficial wounds, such as cuts, scrapes, or minor burns. Their formulation allows for direct application to the skin, where they can exert their antimicrobial effects without needing penetration into deeper tissues.

When dealing with deep penetrating wounds, however, the risk of a more systemic infection and the potential for inadequate distribution of the topical agent make these treatments less appropriate. Deeper tissues may require systemic therapy or more extensive intervention to ensure that the infection is adequately treated throughout the tissue layers. This signifies the limitation of topical anti-infectives, emphasizing their utility primarily in superficial wounds, while deeper injuries necessitate a different approach for effective treatment.