Do anticholinesterase agents increase muscle tone?

Anticholinesterase agents function by inhibiting the enzyme acetylcholinesterase, which leads to an increase in the concentration of acetylcholine at the neuromuscular junction and parasympathetic synapses. This increased availability of acetylcholine enhances cholinergic signaling, which can lead to increased muscle tone.

In the context of muscle function, this effect is particularly relevant in conditions such as myasthenia gravis, where muscle weakness is a significant issue. By increasing acetylcholine levels, anticholinesterase agents promote better communication between nerves and muscles, thereby enhancing muscle contractions and overall muscle tone.

Therefore, stating that anticholinesterase agents increase muscle tone is accurate, as their action leads to improved muscle response and strength by augmenting the neural transmission at the neuromuscular junction.